evaluation of polymer concentration effect on doxycycline hyclate drug release from in situforming system based on poly(lactide-co-glycolide)

in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. also, a new method to stabilize drug in release medium was developed. the structure of prepared membranes is explained by scanning electron microscopy ()sem) to evaluate the surficial and cross-sectional structures of polymer matrices. with increasing in polymer concentration, surface porosity decreased, membrane structure became denser, burst decreased and drug release time increased.